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C188-9 (b)

CAS No. 425373-68-8

C188-9 (b)( C 188-9 )

Catalog No. M14443 CAS No. 425373-68-8

A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    C188-9 (b)
  • Note
    Research use only, not for human use.
  • Brief Description
    A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand.
  • Description
    A novel small-molecule STAT3 inhibitor with Ki of 12.4 nM; inhibits STAT3 binding to its pY-peptide ligand, suppresses cytokine-stimulated pSTAT3, reduces constitutive pSTAT3 activity, and inhibits anchorage dependent and independent growth of in multiple HNSCC cell lines; prevents tumor xenograft growth, modulates many STAT3-regulated genes involved in oncogenesis and radioresistance in vivo.Solid Tumors Phase 1 Clinical.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    C 188-9
  • Pathway
    JAK/STAT Signaling
  • Target
    STAT
  • Recptor
    STAT
  • Research Area
    Cancer
  • Indication
    Solid Tumors

Chemical Information

  • CAS Number
    425373-68-8
  • Formula Weight
    469.555
  • Molecular Formula
    C28H23NO4S
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    N-(1',2-dihydroxy-[1,2'-binaphthalen]-4'-yl)-4-ethylbenzenesulfonamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Redell MS, et al. Blood. 2011 May 26;117(21):5701-9. 2. Bharadwaj U, et al. Oncotarget. 2016 May 3;7(18):26307-30. 3. Jung KH, et al. Clin Cancer Res. 2017 Sep 15;23(18):5537-5546. 4. Minus MB, et al. Angew Chem Int Ed Engl. 2015 Oct 26;54(44):13085-9.
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